Title : Prostaglandin E2 promotes hepatocellular carcinoma cell invasion through upregulation of YB-1 protein expression.

Pub. Date : 2014 Mar

PMID : 24378923






3 Functional Relationships(s)
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1 Src and EGFR were both activated by PGE2, which in turn increased the phosphorylation levels of p44/42 MAPK. Dinoprostone epidermal growth factor receptor Homo sapiens
2 Src, EGFR and p44/42 MAPK were all involved in PGE2-induced YB-1 expression. Dinoprostone epidermal growth factor receptor Homo sapiens
3 These findings reveal that PGE2 upregulated YB-1 expression through the EP1/Src/EGFR/p44/42 MAPK/mTOR pathway, which greatly enhanced HCC cell invasion. Dinoprostone epidermal growth factor receptor Homo sapiens