Pub. Date : 2013
PMID : 24367279
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amyloid-like inclusions have been associated with Huntington"s disease (HD), which is caused by expanded polyglutamine repeats in the Huntingtin protein. | polyglutamine | huntingtin | Drosophila melanogaster |
| 2 | We have generated a Drosophila model of cardiac amyloidosis that exhibits accumulation of PolyQ aggregates and oxidative stress in myocardial cells, upon heart-specific expression of Huntingtin protein fragments (Htt-PolyQ) with disease-causing poly-glutamine repeats (PolyQ-46, PolyQ-72, and PolyQ-102). | polyglutamine | huntingtin | Drosophila melanogaster |
| 3 | We have generated a Drosophila model of cardiac amyloidosis that exhibits accumulation of PolyQ aggregates and oxidative stress in myocardial cells, upon heart-specific expression of Huntingtin protein fragments (Htt-PolyQ) with disease-causing poly-glutamine repeats (PolyQ-46, PolyQ-72, and PolyQ-102). | polyglutamine | huntingtin | Drosophila melanogaster |
| 4 | Cardiac expression of GFP-tagged Htt-PolyQs resulted in PolyQ length-dependent functional defects that included increased incidence of arrhythmias and extreme cardiac dilation, accompanied by a significant decrease in contractility. | polyglutamine | huntingtin | Drosophila melanogaster |
| 5 | Cardiac expression of GFP-tagged Htt-PolyQs resulted in PolyQ length-dependent functional defects that included increased incidence of arrhythmias and extreme cardiac dilation, accompanied by a significant decrease in contractility. | polyglutamine | huntingtin | Drosophila melanogaster |