Title : IFNL4-ΔG genotype is associated with slower viral clearance in hepatitis C, genotype-1 patients treated with sofosbuvir and ribavirin.

Pub. Date : 2014 Jun 1

PMID : 24367041






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 IFNL4-DeltaG genotype is associated with slower viral clearance in hepatitis C, genotype-1 patients treated with sofosbuvir and ribavirin. Ribavirin interferon lambda 4 (gene/pseudogene) Homo sapiens
2 We report that in patients treated with the DAA sofosbuvir along with RBV, IFNL4-DeltaG is associated with slower early viral decay, due to slower loss of free virus (P = .039) and decreased drug efficacy (P = .048), suggesting functional relevance of IFN-lambda4 in IFN-alpha-free DAA therapies. Ribavirin interferon lambda 4 (gene/pseudogene) Homo sapiens