Pub. Date : 2014 Mar
PMID : 24366007
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Notably, the levels of nutlin-3-induced ROS were correlated with the mitochondrial translocation of p53 and this induction was prevented by PFT-mu, an inhibitor of the mitochondrial translocation of p53. | nutlin 3 | tumor protein p53 | Homo sapiens |
| 2 | Notably, the levels of nutlin-3-induced ROS were correlated with the mitochondrial translocation of p53 and this induction was prevented by PFT-mu, an inhibitor of the mitochondrial translocation of p53. | nutlin 3 | tumor protein p53 | Homo sapiens |
| 3 | Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis. | nutlin 3 | tumor protein p53 | Homo sapiens |
| 4 | Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis. | nutlin 3 | tumor protein p53 | Homo sapiens |