Title : Abrogating G₂/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.

Pub. Date : 2014 Apr

PMID : 24365782






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 As expected, the enhancement in cisplatin toxicity was accompanied by a decrease in the inactive phosphorylated form of cyclin-dependent kinase 1 (CDK1), a key substrate of WEE1, which is indicative of G 2/M checkpoint inactivation. Cisplatin cyclin dependent kinase 1 Homo sapiens
2 As expected, the enhancement in cisplatin toxicity was accompanied by a decrease in the inactive phosphorylated form of cyclin-dependent kinase 1 (CDK1), a key substrate of WEE1, which is indicative of G 2/M checkpoint inactivation. Cisplatin cyclin dependent kinase 1 Homo sapiens