Title : Dose-dependent effects of deprenyl on CSF monoamine metabolites in patients with Alzheimer's disease.

Pub. Date : 1987

PMID : 2436247






1 Functional Relationships(s)
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1 These dose-dependent reductions are consistent with in vitro biochemical and anatomical data from primate brain suggesting that at low doses of deprenyl, MAO-B inhibition might be expected to selectively affect dopamine and serotonin-containing neurons, while at higher doses (which lead to MAO-A as well as MAO-B inhibition), noradrenergic neurons may become relatively more affected by the drug. Serotonin monoamine oxidase B Homo sapiens