Title : Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models.

Pub. Date : 2014 Feb

PMID : 24362330






2 Functional Relationships(s)
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Protein Name
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1 Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models. Digoxin ATP binding cassette subfamily B member 1 Homo sapiens
2 CONCLUSION: PMA significantly inhibited P-gp-mediated efflux of digoxin in both Caco-2 and MDCKII-MDR1 cell monolayers via PKC activation. Digoxin ATP binding cassette subfamily B member 1 Homo sapiens