Title : Pranlukast inhibits renal epithelial cyst progression via activation of AMP-activated protein kinase.

Pub. Date : 2014 Feb 5

PMID : 24360935






3 Functional Relationships(s)
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1 Instead, it reduced cAMP-activated chloride secretion and proliferation of MDCK cells in an AMP-activated protein kinase (AMPK)-dependent manner and had no effect on CFTR protein expression. Cyclic AMP protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens
2 Instead, it reduced cAMP-activated chloride secretion and proliferation of MDCK cells in an AMP-activated protein kinase (AMPK)-dependent manner and had no effect on CFTR protein expression. Cyclic AMP protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens
3 These results indicate that pranlukast retards renal epithelial cyst progression by inhibiting cAMP-activated chloride secretion and cell proliferation via CaMKKbeta-AMPK-mTOR pathway. Cyclic AMP protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens