Title : Macrophage-mediated glucolipotoxicity via myeloid-related protein 8/toll-like receptor 4 signaling in diabetic nephropathy.

Pub. Date : 2014 Aug

PMID : 24357461






1 Functional Relationships(s)
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1 In cultured macrophages, combinatorial treatment with high glucose and palmitate amplifies MRP8 expression in a Tlr4-dependent manner, and recombinant MRP8 protein markedly increases gene expression of the inflammatory cytokines interleukin-1beta and tumor necrosis factor alpha. Glucose interleukin 1 beta Mus musculus