Title : scyllo-Inositol promotes robust mutant Huntingtin protein degradation.

Pub. Date : 2014 Feb 7

PMID : 24352657






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have used an established cell-based assay employing a PC12 cell line overexpressing truncated exon 1 of Htt with a 103-residue polyQ expansion that yields polyQ-Htt aggregates to investigate the fate of polyQ-Htt-drug complexes. polyglutamine huntingtin Rattus norvegicus
2 We have used an established cell-based assay employing a PC12 cell line overexpressing truncated exon 1 of Htt with a 103-residue polyQ expansion that yields polyQ-Htt aggregates to investigate the fate of polyQ-Htt-drug complexes. polyglutamine huntingtin Rattus norvegicus
3 In light of these properties, we investigated the effect of scyllo-inositol on polyQ-Htt accumulation. polyglutamine huntingtin Rattus norvegicus