Title : Telmisartan activates endogenous peroxisome proliferator-activated receptor-δ and may have anti-fibrotic effects in human mesangial cells.

Pub. Date : 2014 May

PMID : 24352213






2 Functional Relationships(s)
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1 In the HMC, both GW0742, an authentic PPAR-delta agonist, and telmisartan enhanced PPAR response element (PPRE)-luciferase activity dose dependently, and these increases were blunted by GSK0660, a specific PPAR-delta antagonist, but not by GW9662, a PPAR-gamma antagonist. GW0742 peroxisome proliferator activated receptor delta Homo sapiens
2 In the HMC, both GW0742, an authentic PPAR-delta agonist, and telmisartan enhanced PPAR response element (PPRE)-luciferase activity dose dependently, and these increases were blunted by GSK0660, a specific PPAR-delta antagonist, but not by GW9662, a PPAR-gamma antagonist. GW0742 peroxisome proliferator activated receptor delta Homo sapiens