Title : Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17β-estradiol biosynthesis in endometrial carcinoma microenvironment.

Pub. Date : 2014 Jul 15

PMID : 24347287






2 Functional Relationships(s)
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1 Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17beta-estradiol biosynthesis in endometrial carcinoma microenvironment. Estradiol interleukin 6 Homo sapiens
2 When cocultured with 17beta-estradiol (E2 )-treated cancer cells, aromatase mRNA in stromal cells was significantly elevated and increased IL-6 protein levels were detected in E2 -treated culture medium. Estradiol interleukin 6 Homo sapiens