Title : Electrochemical analysis of the fibrillation of Parkinson's disease α-synuclein.

Pub. Date : 2014 Feb 21

PMID : 24343298






1 Functional Relationships(s)
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1 Here we show that the extent of aggregation of alpha-synuclein (alphaSN), involved in Parkinson"s disease and other neurodegenerative disorders, can be electrochemically monitored by oxidizing tyrosine (Tyr) residues surface-exposed in monomeric alphaSN and buried in fibrillated alphaSN adsorbed onto graphite electrodes. Graphite synuclein alpha Homo sapiens