Title : Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation.

Pub. Date : 2014 Jan 31

PMID : 24338014






1 Functional Relationships(s)
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1 From the crystal structure of plasminogen, we propose that plasmin ligands such as phosphoglycerate kinase induce a conformational change in reduced kringle 5 that leads to attack by the Cys(541) thiolate anion on the Cys(536) sulfur atom of the Cys(512)-Cys(536) disulfide bond, resulting in reduction of the bond by thiol/disulfide exchange. Sulfhydryl Compounds plasminogen Homo sapiens