Title : BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling.

Pub. Date : 2014 Mar

PMID : 24335212






1 Functional Relationships(s)
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1 Our results indicated that phospholipase Cgamma (PLCgamma) is involved in the CB1 receptor-mediated synaptic effect of BDNF, because the BDNF effect was blocked in the presence of the broad-spectrum PLC inhibitors U-73122 and edelfosine, whereas the inactive analog U-73343 did not alter the suppressive effect of BDNF at inhibitory synapses. U 73343 cannabinoid receptor 1 (brain) Mus musculus