Title : Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS.

Pub. Date : 2014 Jan

PMID : 24332999






1 Functional Relationships(s)
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1 Reactive oxygen species played a key role since p47(phox)KO mice were resistant to Ang II-induced TACE phosphorylation and activation with preservation of myocardial ACE2 which dampened Ang II-induced cardiac dysfunction and hypertrophy. Reactive Oxygen Species angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus