Title : Telaprevir is a substrate and moderate inhibitor of P-glycoprotein, a strong inductor of ABCG2, but not an activator of PXR in vitro.

Pub. Date : 2014 Feb

PMID : 24332840






1 Functional Relationships(s)
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1 In LS180 cells, telaprevir strongly induced mRNA expression of ABCG2 (4.3-fold at 30 mumol/L) and weakly induced ABCB11, CYP2C19 and UGT1A3. telaprevir ATP binding cassette subfamily B member 11 Homo sapiens