Title : Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway.

Pub. Date : 2013 Dec 5

PMID : 24309939






1 Functional Relationships(s)
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1 Molecular docking analysis suggested that WA could bind to HRas-GTP, causing accumulation of Ras-GTP and excessive activation of Raf/ERK/p53-p21. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens