Title : Protein kinase C stimulation increases the transforming ability of the polyoma virus middle T antigen.

Pub. Date : 1986 Nov 14

PMID : 2430571






2 Functional Relationships(s)
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Protein Name
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1 This TPA (hence probably protein kinase C)-enhanced association of mT with pp60c-src was accompanied by a large increase in the transforming ability of mT as indicated by a much enhanced ability of TPA-treated mT-1 cells producing submaximal levels of mT to proliferate while suspended in semi-solid medium and to form foci on confluent monolayers of normal F111 cells. Tetradecanoylphorbol Acetate SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
2 This TPA (hence probably protein kinase C)-enhanced association of mT with pp60c-src was accompanied by a large increase in the transforming ability of mT as indicated by a much enhanced ability of TPA-treated mT-1 cells producing submaximal levels of mT to proliferate while suspended in semi-solid medium and to form foci on confluent monolayers of normal F111 cells. Tetradecanoylphorbol Acetate SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus