Title : Sodium valproate induces cell senescence in human hepatocarcinoma cells.

Pub. Date : 2013 Dec 4

PMID : 24304587






3 Functional Relationships(s)
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1 Low dose SVP treatment also increased acetylation of histone H3 and H4 on p21 promoter, accompanied by up-regulation of p21 and down-regulation of RB phosphorylation. Valproic Acid H3 histone pseudogene 16 Homo sapiens
2 Low dose SVP treatment also increased acetylation of histone H3 and H4 on p21 promoter, accompanied by up-regulation of p21 and down-regulation of RB phosphorylation. Valproic Acid H3 histone pseudogene 16 Homo sapiens
3 These observations suggested that a low dose of SVP could induce cell senescence in hepatocarcinoma cells, which might correlate with hyperacetylation of histone H3 and H4, up-regulation of p21, and inhibition of RB phosphorylation. Valproic Acid H3 histone pseudogene 16 Homo sapiens