Title : Junctional adhesion molecule-A suppresses platelet integrin αIIbβ3 signaling by recruiting Csk to the integrin-c-Src complex.

Pub. Date : 2014 Feb 27

PMID : 24300854






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 C-terminal Src kinase (Csk) binds to tyrosine phosphorylated JAM-A through its Src homology 2 domain. Tyrosine C-terminal Src kinase Homo sapiens
2 C-terminal Src kinase (Csk) binds to tyrosine phosphorylated JAM-A through its Src homology 2 domain. Tyrosine C-terminal Src kinase Homo sapiens
3 Our results strongly suggest that tyrosine-phosphorylated JAM-A is a Csk-binding protein and functions as an endogenous inhibitor of integrin signaling. Tyrosine C-terminal Src kinase Homo sapiens
4 Upon agonist stimulation, JAM-A is dephosphorylated on the tyrosine, allowing the dissociation of Csk from the integrin complex, and thus facilitating outside-in signaling. Tyrosine C-terminal Src kinase Homo sapiens