Pub. Date : 2014 Mar
PMID : 24299737
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
2 | Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
3 | Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
4 | Basal and TCDD-, 17beta-estradiol (E2)-, or TCDD + E2-dependent recruitment of AHR, ARNT, ERalpha, NCoA3, and RNA polymerase II to CYP1B1 as well as CYP1B1 mRNA levels were abolished in MCF7-AHR((ko)) and MDA-MB-231 AHR(ko) cells. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
5 | Our data show that AHR and ARNT play critical roles in the basal, TCDD, and E2-induced regulation of CYP1B1 but also reveal distinct roles for both proteins in ERalpha transactivation. | Polychlorinated Dibenzodioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |