Title : Andrographolide antagonizes cigarette smoke extract-induced inflammatory response and oxidative stress in human alveolar epithelial A549 cells through induction of microRNA-218.

Pub. Date : 2013 Dec

PMID : 24298938






3 Functional Relationships(s)
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1 We found that andrographolide pretreatment significantly restored the glutathione level in CSE-exposed A549 cells, coupled with reduced inhibitor kappaB (IkappaB)-alpha phosphorylation and p65 nuclear translocation and interleukin (IL)-8 and IL-6 secretion. andrographolide interleukin 6 Homo sapiens
2 In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production. andrographolide interleukin 6 Homo sapiens
3 In contrast, miR-218 silencing enhanced IkappaB-alpha phosphorylation and p65 nuclear accumulation in cells with andrographolide pretreatment and reversed andrographolide-mediated reduction of IL-6 and IL-8 production. andrographolide interleukin 6 Homo sapiens