Pub. Date : 2014 Feb
PMID : 24298020
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC. | polyglutamine | VRK serine/threonine kinase 2 | Homo sapiens |
| 2 | Interestingly, VRK2-mediated downregulation of TRiC increased aggregate formation of a polyQ-expanded huntingtin fragment. | polyglutamine | VRK serine/threonine kinase 2 | Homo sapiens |
| 3 | Taken together, these results demonstrate that VRK2 is crucial to regulate the ubiquitination-proteosomal degradation of TRiC, which controls folding of polyglutamine proteins involved in Huntington"s disease. | polyglutamine | VRK serine/threonine kinase 2 | Homo sapiens |