Pub. Date : 2015 May
PMID : 24293383
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study was conducted to investigate the potential effects of diallyl disulfide (DADS) on carbon tetrachloride (CCl4 )-induced acute hepatotoxicity and to determine the molecular mechanisms of protection offered by DADS in rats. | diallyl disulfide | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 2 | The single oral dose of CCl4 (2 mL/kg) caused a significant elevation in serum aspartate and alanine aminotransferase activities, which decreased upon pretreatment with DADS. | diallyl disulfide | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 3 | These results indicate that the protective effects of DADS against CCl4 -induced hepatotoxicity possibly involve mechanisms related to its ability to induce antioxidant or detoxifying enzymes by activating Nrf2 and block metabolic activation of CCl4 by suppressing CYP2E1. | diallyl disulfide | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 4 | These results indicate that the protective effects of DADS against CCl4 -induced hepatotoxicity possibly involve mechanisms related to its ability to induce antioxidant or detoxifying enzymes by activating Nrf2 and block metabolic activation of CCl4 by suppressing CYP2E1. | diallyl disulfide | C-C motif chemokine ligand 4 | Rattus norvegicus |