Title : Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.

Pub. Date : 2014 Jan 9

PMID : 24289924






3 Functional Relationships(s)
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1 We further show that cellular ATP level might act as a molecular switch for Thr55 phosphorylation on the p21 promoter, indicating that TAF1 is a cellular ATP sensor. Adenosine Triphosphate H3 histone pseudogene 16 Homo sapiens
2 We further show that cellular ATP level might act as a molecular switch for Thr55 phosphorylation on the p21 promoter, indicating that TAF1 is a cellular ATP sensor. Adenosine Triphosphate H3 histone pseudogene 16 Homo sapiens
3 Upon DNA damage, cells undergo PARP-1-dependent ATP depletion, which is correlated with reduced TAF1 kinase activity and Thr55 phosphorylation, resulting in p21 activation. Adenosine Triphosphate H3 histone pseudogene 16 Homo sapiens