Title : New effective gonadotropin releasing hormone antagonists with minimal potency for histamine release in vitro.

Pub. Date : 1986 Oct

PMID : 2428978






3 Functional Relationships(s)
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1 New effective gonadotropin releasing hormone antagonists with minimal potency for histamine release in vitro. Histamine gonadotropin releasing hormone 1 Rattus norvegicus
2 In vitro: the affinity for the pituitary GnRH receptor was measured as was the ability of the analogues to inhibit GnRH-stimulated release of luteinizing hormone (LH) by dispersed anterior pituitary cells in culture and to release histamine from rat mast cells. Histamine gonadotropin releasing hormone 1 Rattus norvegicus
3 Release of histamine was observed at doses 10-25 times that required for [Ac-D2Nal1,D4FPhe2,DTrp3,DArg6]-GnRH. Histamine gonadotropin releasing hormone 1 Rattus norvegicus