Title : Curcumin promotes neurite outgrowth via reggie-1/flotillin-2 in cortical neurons.

Pub. Date : 2014 Jan 24

PMID : 24287376






3 Functional Relationships(s)
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1 We discovered that curcumin treatment could promote the number of processes, mean process length, and maximum process length of primary neurons, which were inhibited by reggie-1 siRNAs or extracellular signal-regulated kinase (ERK) 1/2 antagonist. Curcumin mitogen-activated protein kinase 3 Homo sapiens
2 Furthermore, curcumin-induced neurite growth was related to the ERK1/2 phosphorylation, which was blocked by reggie-1 knockdown. Curcumin mitogen-activated protein kinase 3 Homo sapiens
3 Overall, our results implied that curcumin could mediate neurite outgrowth through reggie-1 and ERK1/2 pathway. Curcumin mitogen-activated protein kinase 3 Homo sapiens