Pub. Date : 2014 Jan 1
PMID : 24285838
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously reported that cyclooxygenase-2 (Cox-2)-dependent PGE2 synthesis regulates macrophage matrix metalloproteinase (MMP)-9 expression, an endopeptidase that participates in diverse pathologic processes. | Dinoprostone | matrix metallopeptidase 9 | Mus musculus |
| 2 | In addition, IL-6 induced MMP-9 expression, suggesting that the observed proteinase expression was regulated by the synthesis of PGE2. | Dinoprostone | matrix metallopeptidase 9 | Mus musculus |
| 3 | However, inhibition of PGE2 synthesis partially suppressed IL-6-mediated induction of MMP-9. | Dinoprostone | matrix metallopeptidase 9 | Mus musculus |