Title : COOH-terminal collagen Q (COLQ) mutants causing human deficiency of endplate acetylcholinesterase impair the interaction of ColQ with proteins of the basal lamina.

Pub. Date : 2014 May

PMID : 24281389






1 Functional Relationships(s)
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Protein Name
Organism
1 The attachment of AChE to the BL is primarily accomplished by the binding of the ColQ collagen domain to the heparan sulfate proteoglycan perlecan and the COOH-terminus to the muscle-specific receptor tyrosine kinase (MuSK), which in turn plays a fundamental role in the development and maintenance of the NMJ. Heparitin Sulfate acetylcholinesterase (Cartwright blood group) Homo sapiens