Title : Promotion of cAMP responsive element-binding protein activity ameliorates radiation-induced suppression of hippocampal neurogenesis in adult mice.

Pub. Date : 2010 Sep

PMID : 24278522






2 Functional Relationships(s)
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1 C57BL/6 male mice were treated with rolipram (1.25 mg/kg, i.p., twice a day for 5 consecutive days) to activate the cAMP/CREB pathway against cranial irradiation (2 Gy) , and were euthanized at 24 h post-irradiation. Rolipram cAMP responsive element binding protein 1 Mus musculus
2 However, the rolipram treatment protected from gamma-irradiation-induced decreases of CREB phosphorylation, and Ki-67 and DCX immunoreactivity in the hippocampal DG. Rolipram cAMP responsive element binding protein 1 Mus musculus