Title : Regioselective synthesis of 4-substituted indoles via C-H activation: a ruthenium catalyzed novel directing group strategy.

Pub. Date : 2013 Dec 20

PMID : 24274038






1 Functional Relationships(s)
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1 A highly regioselective functionalization of indole at the C-4 position by employing an aldehyde functional group as a directing group, and Ru as a catalyst, under mild reaction conditions (open flask) has been uncovered. Aldehydes complement C4A (Rodgers blood group) Homo sapiens