Title : Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of α-N-acetylglucosaminidase to mucopolysaccharidosis type IIIB fibroblasts.

Pub. Date : 2014 Mar 1

PMID : 24266751






1 Functional Relationships(s)
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1 Enzyme replacement therapy for MPS IIIB (mucopolysaccharidosis type IIIB; also known as Sanfilippo B syndrome) has been hindered by inadequate mannose 6 phosphorylation and cellular uptake of rhNAGLU (recombinant human alpha-N-acetylglucosaminidase). Mannose N-acetyl-alpha-glucosaminidase Homo sapiens