Title : Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of α-N-acetylglucosaminidase to mucopolysaccharidosis type IIIB fibroblasts.

Pub. Date : 2014 Mar 1

PMID : 24266751






1 Functional Relationships(s)
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1 Glycosaminoglycan storage was reduced by 60% (P<0.001) to near background levels in MPS IIIB cells after treatment with rhNAGLU-IGF-II, with half-maximal correction at concentrations of 3-12 pM. Glycosaminoglycans N-acetyl-alpha-glucosaminidase Homo sapiens