Title : Dual control of the selectivity in the formal nucleophilic substitution of bromocyclopropanes en route to densely functionalized, chirally rich cyclopropyl derivatives.

Pub. Date : 2013 Dec 6

PMID : 24261655






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The chiral center at C-2 in bromocyclopropane dictates the configuration of the other two stereocenters that are successively installed via a sterically controlled addition of a nucleophile, followed by a thermodynamically driven epimerization of the resulting enolate intermediate. enolate complement C2 Homo sapiens