Title : Inhibition mechanism of P-glycoprotein mediated efflux by mPEG-PLA and influence of PLA chain length on P-glycoprotein inhibition activity.

Pub. Date : 2014 Jan 6

PMID : 24256068






2 Functional Relationships(s)
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1 The depletion of intracellular ATP, which was likely to be a result of partial inhibition of cellular metabolism, was directly correlated with inhibitory potential for P-gp mediated efflux by mPEG-PLA analogues. Adenosine Triphosphate ATP binding cassette subfamily B member 1 Homo sapiens
2 Hence, intracellular ATP-depletion appeared to be possible explanation to the inhibition mechanism of P-gp by mPEG-PLA. Adenosine Triphosphate ATP binding cassette subfamily B member 1 Homo sapiens