Title : Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling.

Pub. Date : 2014 Feb

PMID : 24252946






1 Functional Relationships(s)
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1 In human hepatocytes, metformin robustly suppressed the expression of CYP2B6 induced by both indirect (phenobarbital) and direct CITCO [6-(4-chlorophenyl)imidazo[2,1-b]1,3thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime] activators of human CAR. Phenobarbital cytochrome P450 family 2 subfamily B member 6 Homo sapiens