Title : Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor.

Pub. Date : 2014 Apr

PMID : 24251786






2 Functional Relationships(s)
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1 Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor. Aminoglycosides CF transmembrane conductance regulator Homo sapiens
2 These results provide evidence that NB124 and other synthetic aminoglycosides provide a 10-fold improvement in therapeutic index over gentamicin and other first-generation aminoglycosides, providing a promising treatment for a wide array of CFTR nonsense mutations. Aminoglycosides CF transmembrane conductance regulator Homo sapiens