Title : Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruzi.

Pub. Date : 2014

PMID : 24251576






1 Functional Relationships(s)
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1 Herein, we examine the biosynthetic pathway of T(SH)2, identifying three key points that are susceptible to attack pharmacologically: the activity of the trypanothione reductase (TR), the function of glutamate-cysteine ligase (GCL) and polyamine transport in T. cruzi. Polyamines threonine synthase like 2 Homo sapiens