Pub. Date : 2013 Winter
PMID : 24250670
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 2 | Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 3 | Therefore, the present study was aimed to investigate the effect of D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 4 | The absorptive transport of etoposide was significantly enhanced (p < 0.001) in the presence of verapamil (100 mug/mL) and TPGS (over the concentration range of 0.002- 0.1 mg/mL), suggesting that the inhibition of P-gp located in the intestine may be involved in the enhancement of etoposide absorption. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |