Title : Synthesis and evaluation of 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides as COX-2 and serotonin reuptake inhibitors.

Pub. Date : 2014 Feb

PMID : 24243443






1 Functional Relationships(s)
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1 The compound 2-[2-(4-benzyloxyphenyl)morpholino]ethyl 2-(4-iso-butylphenyl)-propanoate hydrochloride (1k) shows better COX-2 inhibitory activity (IC50 = 0.78 microM) than ibuprofen (IC50 = 7.6 microM), and it simultaneously possesses favorable serotonin reuptake inhibitory activity. Ibuprofen mitochondrially encoded cytochrome c oxidase II Homo sapiens