Title : Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease.

Pub. Date : 2013 Dec

PMID : 24226268






4 Functional Relationships(s)
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1 Here, we report immunohistochemical staining of the Tau-C3 antibody, which recognizes Asp(421)-truncated tau, in a group of AD cases with different extents of cognitive impairment. Aspartic Acid microtubule associated protein tau Homo sapiens
2 Here, we report immunohistochemical staining of the Tau-C3 antibody, which recognizes Asp(421)-truncated tau, in a group of AD cases with different extents of cognitive impairment. Aspartic Acid microtubule associated protein tau Homo sapiens
3 In the hippocampus, we found distinct nonfibrillary aggregates of Asp(421)-truncated tau. Aspartic Acid microtubule associated protein tau Homo sapiens
4 On the other hand, despite in vitro evidence that caspase-3 cleaves monomeric tau at Asp(421), to date, this truncation has not been demonstrated to be executed by this protease in polymeric tau entities. Aspartic Acid microtubule associated protein tau Homo sapiens