Title : Hepatitis C and alcohol exacerbate liver injury by suppression of FOXO3.

Pub. Date : 2013 Dec

PMID : 24225087






3 Functional Relationships(s)
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1 Mice expressing HCV structural proteins on a background of reduced expression of superoxide dismutase 2 (SOD2; Sod2(+/-)) also had increased liver sensitivity to alcohol, with elevated ALT, steatosis, and lobular inflammation. Alcohols superoxide dismutase 2 Homo sapiens
2 Mice expressing HCV structural proteins on a background of reduced expression of superoxide dismutase 2 (SOD2; Sod2(+/-)) also had increased liver sensitivity to alcohol, with elevated ALT, steatosis, and lobular inflammation. Alcohols superoxide dismutase 2 Homo sapiens
3 Elevated ALT was associated with an alcohol-induced decrease in SOD2 and redistribution of FOXO3 to the cytosol. Alcohols superoxide dismutase 2 Homo sapiens