Pub. Date : 2009 Jun
PMID : 24223493
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synthesis and Biological Evaluation of Non-Hydrolizable 1,2,3-Triazole Linked Sialic Acid Derivatives as Neuraminidase Inhibitors. | N-Acetylneuraminic Acid | neuraminidase 1 | Homo sapiens |
| 2 | Our approach is to generate non-natural N-glycosides of sialic acid that are resistant to neuraminidase catalyzed hydrolysis as opposed to the natural O-glycosides. | N-Acetylneuraminic Acid | neuraminidase 1 | Homo sapiens |
| 3 | These novel sialic acid derivatives were then evaluated as potential neuraminidase inhibitors using a 96-well plate fluorescence assay; micromolar IC50 values were observed, comparable to the known sialidase inhibitor Neu5Ac2en. | N-Acetylneuraminic Acid | neuraminidase 1 | Homo sapiens |