Title : Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signaling.

Pub. Date : 2013 Nov 7

PMID : 24201812






3 Functional Relationships(s)
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1 Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signaling. Dichloroacetic Acid mechanistic target of rapamycin kinase Homo sapiens
2 Finally, we demonstrated that the Akt-mTOR signaling pathway, a major negative regulator of autophagy, was suppressed by DCA treatment. Dichloroacetic Acid mechanistic target of rapamycin kinase Homo sapiens
3 To our knowledge, it was the first study to show that DCA induced protective autophagy in LoVo cells, and the potential mechanisms were involved in ROS imbalance and Akt-mTOR signaling pathway suppression. Dichloroacetic Acid mechanistic target of rapamycin kinase Homo sapiens