Pub. Date : 2013 Nov
PMID : 24200065
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effect of acetazolamide on AQP1 and AQP3 expressions in fibroblast-like synoviocytes of rheumatoid arthritis]. | Acetazolamide | aquaporin 1 (Colton blood group) | Homo sapiens |
| 2 | OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). | Acetazolamide | aquaporin 1 (Colton blood group) | Homo sapiens |
| 3 | OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). | Acetazolamide | aquaporin 1 (Colton blood group) | Homo sapiens |
| 4 | OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). | Acetazolamide | aquaporin 1 (Colton blood group) | Homo sapiens |
| 5 | OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). | Acetazolamide | aquaporin 1 (Colton blood group) | Homo sapiens |
| 6 | OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). | Acetazolamide | aquaporin 1 (Colton blood group) | Homo sapiens |
| 7 | OBJECTIVE: To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). | Acetazolamide | aquaporin 1 (Colton blood group) | Homo sapiens |
| 8 | The expressions of AQP1 mRNA and AQP3 mRNA in RAFLSs and OAFLSs were measured by RT-PCR; the expression of AQP1 protein was detected by immunofluorescence in RAFLSs and OAFLSs treated with the same concentration of acetazolamide (10(-4) mol/L) for different time (24, 48, 72 hours). | Acetazolamide | aquaporin 1 (Colton blood group) | Homo sapiens |
| 9 | Different concentrations of acetazolamide (10(-4), 10(-6), 10(-8) mol/L) were able to significantly decrease the expression level of AQP1 mRNA in RAFLSs (P<0.05) in a time- and dose-dependent manner. | Acetazolamide | aquaporin 1 (Colton blood group) | Homo sapiens |
| 10 | Acetazolamide can reduce the expression of AQP1 rather than AQP3 in RAFLSs. | Acetazolamide | aquaporin 1 (Colton blood group) | Homo sapiens |