Title : [Changes and regulatory mechanism of tight junction proteins in in vitro model of lead-induced blood-brain barrier injury].

Pub. Date : 2013 Nov

PMID : 24200059






1 Functional Relationships(s)
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1 Western blotting showed that the expressions of ZO-1, occludin and claudin-5 were significantly reduced after 2.5 mumol/L lead treatment (P<0.05); the phosphorylation levels of ERK1/2, JNK, p38, AKT473 and AKT308 were elevated significantly (P<0.05); ERK1/2 inhibitor PD98059 and PI3K inhibitor LY294002 reversed the lead effects. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens