Title : Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ.

Pub. Date : 2014 Jan

PMID : 24200052






2 Functional Relationships(s)
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1 Interaction between PPARgamma Pro12Ala and IL6 -174G>C improved prediction of high fasting blood glucose (chi(2)=13.99; df=1; p<0.001). Glucose interleukin 6 Homo sapiens
2 PPARgamma Ala12 variant was found protective in patients with IL6 -174GG genotype (OR=0.10; 95% CI: 0.02-0.57, p=0.01), while in the case of IL6 -174C allele carriers, for PPARgamma Ala12 carriers, larger odds for high glucose levels compared with Pro12 variant were observed (OR=2.39; 95% CI: 1.11-5.17, p=0.026). Glucose interleukin 6 Homo sapiens