Title : Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence.

Pub. Date : 2013

PMID : 24194639






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Moreover, we report here, for the first time, that in combined therapy, IFNalpha induces a clear process of autophagosome formation, and prior treatment with chloroquine, an autophagy inhibitor, is able to significantly reduce IFNalpha/bozepinib-induced cell death. Chloroquine interferon alpha 1 Homo sapiens
2 Moreover, we report here, for the first time, that in combined therapy, IFNalpha induces a clear process of autophagosome formation, and prior treatment with chloroquine, an autophagy inhibitor, is able to significantly reduce IFNalpha/bozepinib-induced cell death. Chloroquine interferon alpha 1 Homo sapiens