Title : Inhibition of dipeptidyl peptidase IV (DPP-IV) by tryptophan containing dipeptides.

Pub. Date : 2013 Dec

PMID : 24193022






2 Functional Relationships(s)
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1 Novel DPP-IV inhibitors were identified comprising of three potent dipeptides (Trp-Arg, Trp-Lys and Trp-Leu) with half maximum inhibitory concentration (IC50 values) <45 muM. Tryptophan latexin Homo sapiens
2 Phosphorylation resulted in an increase in DPP-IV IC50, giving values of 482.1 +- 12.9 and >11,000 muM for Trp-Thr and Trp-pThr, respectively. Tryptophan latexin Homo sapiens